Staufen: from embryo polarity to cellular stress and neurodegeneration.
Identifieur interne : 001290 ( Main/Exploration ); précédent : 001289; suivant : 001291Staufen: from embryo polarity to cellular stress and neurodegeneration.
Auteurs : Leandro Julian Martinez Tosar [Argentine] ; Maria Gabriela Thomas ; Maria Veronica Baez ; Irene Ibanez ; Ariel Chernomoretz ; Graciela Lidia BoccaccioSource :
- Frontiers in bioscience (Scholar edition) [ 1945-0524 ] ; 2012.
Descripteurs français
- KwdFr :
- ARN (génétique), ARN (métabolisme), ARN messager (génétique), ARN messager (métabolisme), Animaux, Humains, Protéines de liaison à l'ARN (génétique), Protéines de liaison à l'ARN (métabolisme), Protéines de liaison à l'ARN (physiologie), Ribonucléoprotéines (génétique), Ribonucléoprotéines (métabolisme), Stabilité de l'ARN, Transport des ARN.
- MESH :
- génétique : ARN, ARN messager, Protéines de liaison à l'ARN, Ribonucléoprotéines.
- métabolisme : ARN, ARN messager, Protéines de liaison à l'ARN, Ribonucléoprotéines.
- physiologie : Protéines de liaison à l'ARN.
- Animaux, Humains, Stabilité de l'ARN, Transport des ARN.
English descriptors
- KwdEn :
- Animals, Humans, RNA (genetics), RNA (metabolism), RNA Stability, RNA Transport, RNA, Messenger (genetics), RNA, Messenger (metabolism), RNA-Binding Proteins (genetics), RNA-Binding Proteins (metabolism), RNA-Binding Proteins (physiology), Ribonucleoproteins (genetics), Ribonucleoproteins (metabolism).
- MESH :
- chemical , genetics : RNA, RNA, Messenger, RNA-Binding Proteins, Ribonucleoproteins.
- chemical , metabolism : RNA, RNA, Messenger, RNA-Binding Proteins, Ribonucleoproteins.
- chemical , physiology : RNA-Binding Proteins.
- Animals, Humans, RNA Stability, RNA Transport.
Abstract
Staufen is a double-stranded RNA-binding protein that forms RNA granules by RNA-dependent and -independent interactions. Staufen was initially described in Drosophila as a key molecule for targeting maternal mRNAs. In vertebrates, two highly similar paralogs with several splicing variants mediate mRNA transport, thus affecting neuron plasticity, learning and memory. Staufen also regulates translation and mRNA decay. In recent years, Staufen was shown to be an important regulatory component of stress granules (SGs), which are large aggregates of silenced mRNPs specifically induced upon acute cellular stress. SGs contribute to cell survival by reprogramming translation and inhibiting pro-apoptotic pathways, and Staufen appears to negatively modulate SG formation by several mechanisms. More recently, mammalian Staufen was found in RNA granules and pathological cytoplasmic aggregates related to SGs containing huntingtin, TDP43, FUS/TLS or FMRP. In addition, Staufen binds CUG repeats present in mutant RNAs causative of degenerative conditions, thus ameliorating disease. Finally, Staufen affects HIV and influenza infection at several levels. Collectively, these observations unveil important roles for Staufen-mediated post-transcriptional regulation in a growing number of human diseases.
DOI: 10.2741/277
PubMed: 22202069
Affiliations:
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Le document en format XML
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first="Graciela Lidia" last="Boccaccio">Graciela Lidia Boccaccio</name></author></analytic><series><title level="j">Frontiers in bioscience (Scholar edition)</title><idno type="eISSN">1945-0524</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Humans</term><term>RNA (genetics)</term><term>RNA (metabolism)</term><term>RNA Stability</term><term>RNA Transport</term><term>RNA, Messenger (genetics)</term><term>RNA, Messenger (metabolism)</term><term>RNA-Binding Proteins (genetics)</term><term>RNA-Binding Proteins (metabolism)</term><term>RNA-Binding Proteins (physiology)</term><term>Ribonucleoproteins (genetics)</term><term>Ribonucleoproteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN (génétique)</term><term>ARN (métabolisme)</term><term>ARN messager (génétique)</term><term>ARN messager 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Staufen was initially described in Drosophila as a key molecule for targeting maternal mRNAs. In vertebrates, two highly similar paralogs with several splicing variants mediate mRNA transport, thus affecting neuron plasticity, learning and memory. Staufen also regulates translation and mRNA decay. In recent years, Staufen was shown to be an important regulatory component of stress granules (SGs), which are large aggregates of silenced mRNPs specifically induced upon acute cellular stress. SGs contribute to cell survival by reprogramming translation and inhibiting pro-apoptotic pathways, and Staufen appears to negatively modulate SG formation by several mechanisms. More recently, mammalian Staufen was found in RNA granules and pathological cytoplasmic aggregates related to SGs containing huntingtin, TDP43, FUS/TLS or FMRP. In addition, Staufen binds CUG repeats present in mutant RNAs causative of degenerative conditions, thus ameliorating disease. Finally, Staufen affects HIV and influenza infection at several levels. Collectively, these observations unveil important roles for Staufen-mediated post-transcriptional regulation in a growing number of human diseases.</div></front></TEI><affiliations><list><country><li>Argentine</li></country></list><tree><noCountry><name sortKey="Baez, Maria Veronica" sort="Baez, Maria Veronica" uniqKey="Baez M" first="Maria Veronica" last="Baez">Maria Veronica Baez</name><name sortKey="Boccaccio, Graciela Lidia" sort="Boccaccio, Graciela Lidia" uniqKey="Boccaccio G" first="Graciela Lidia" last="Boccaccio">Graciela Lidia Boccaccio</name><name sortKey="Chernomoretz, Ariel" sort="Chernomoretz, Ariel" uniqKey="Chernomoretz A" first="Ariel" last="Chernomoretz">Ariel Chernomoretz</name><name sortKey="Ibanez, Irene" sort="Ibanez, Irene" uniqKey="Ibanez I" first="Irene" last="Ibanez">Irene Ibanez</name><name sortKey="Thomas, Maria Gabriela" sort="Thomas, Maria Gabriela" uniqKey="Thomas M" first="Maria Gabriela" last="Thomas">Maria Gabriela Thomas</name></noCountry><country name="Argentine"><noRegion><name sortKey="Tosar, Leandro Julian Martinez" sort="Tosar, Leandro Julian Martinez" uniqKey="Tosar L" first="Leandro Julian Martinez" last="Tosar">Leandro Julian Martinez Tosar</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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